ABSTRACT
Study of the disease patterns and clinical evaluation of myelodysplastic syndrome [MDS]. A retrospective analysis was carried out on 85 patients, with MDS who were followed up over a period of 23 years at Jordan University Hospital, Amman, Jordan. Cases were analyzed according to the French, American and British Classification. Of the 85 patients, 42 [49.4%] were females and 43 [50%] males; mean age was 59 +/- 19 years [range 18-88]. Most subtypes found in patients were refractory anemia [RA] in 27 [31.8%] and RA with excess blasts [RAEB] in 28 [32.9%]. Adverse prognostic indicators were RAEB subtype and requirement for blood transfusion. Our findings showed that MDSs appeared at a younger age and tended to be of the aggressive subtype. Chronic myelomonocytic leukemia subtype seemed to appear dominantly in men